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Food and Drug Administration (FDA) for human use

Clinical trials have confirmed the drugs efficacy in reducing the incidence of heart failure and improving exercise tolerance

Same endpoint as the claim

In preclinical models, NNMT inhibition has been shown to mimic and boost exercise-mediated improvements in muscle function, even in sedentary subjects

Most commonly reported side effects: Mild nasal irritation or burning (around 18% in some surveys) Temporary dryness or congestion Headache (around 9%) Occasional bloody nose (around 78%) Less commonly, a small percentage of users report a temporary worsening of underlying symptoms